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D Moneta Selected Research

4- demethoxy- 3'- deamino- 3'- aziridinyl- 4'- methylsulfonyldaunorubicin

3/2003Predicting the maximum-tolerated dose of PNU-159548 (4-demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulphonyl-daunorubicin) in humans using CFU-GM clonogenic assays and prospective validation.
4/2001PNU-159548, a novel cytotoxic antitumor agent with a low cardiotoxic potential.
3/2001Pharmacological and toxicological aspects of 4-demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulphonyl-daunorubicin (PNU-159548): a novel antineoplastic agent.

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D Moneta Research Topics

Disease

6Seizures (Absence Seizure)
09/2002 - 01/2000
2Cardiotoxicity
04/2001 - 03/2001
1Pancreatitis
11/2004
1Neutropenia
03/2003
1Thrombocytopenia (Thrombopenia)
03/2003
1Atrophy
04/2001
1Body Weight (Weight, Body)
04/2001
1Cardiomyopathies (Cardiomyopathy)
04/2001
1Neoplasms (Cancer)
03/2001
1Carcinoma (Carcinomatosis)
03/2001
1Astrocytoma (Pilocytic Astrocytoma)
03/2001
1Renal Cell Carcinoma (Grawitz Tumor)
03/2001
1Melanoma (Melanoma, Malignant)
03/2001
1Status Epilepticus (Complex Partial Status Epilepticus)
07/2000
1Necrosis
07/2000

Drug/Important Bio-Agent (IBA)

34- demethoxy- 3'- deamino- 3'- aziridinyl- 4'- methylsulfonyldaunorubicinIBA
03/2003 - 03/2001
3Kainic Acid (Kainate)IBA
09/2002 - 01/2000
2Doxorubicin (Adriamycin)FDA LinkGeneric
04/2001 - 03/2001
2Messenger RNA (mRNA)IBA
01/2001 - 07/2000
2Proteins (Proteins, Gene)FDA Link
10/2000 - 01/2000
1trypsinogen activation peptideIBA
11/2004
1Glutamic Acid (Glutamate)FDA Link
09/2002
1Somatostatin Receptors (Somatostatin Receptor)IBA
09/2002
1Octreotide (Sandostatin)FDA LinkGeneric
09/2002
1BIM 23120IBA
09/2002
1L 779976IBA
09/2002
1Neuropeptide YIBA
01/2002
1Anticonvulsants (Antiepileptic Drugs)IBA
01/2002
1AnthracyclinesIBA
04/2001
1Idarubicin (4 Demethoxydaunorubicin)FDA LinkGeneric
04/2001
1Troponin T (Troponin T1)IBA
04/2001
1Pharmaceutical PreparationsIBA
03/2001
1PTX3 proteinIBA
01/2001
1N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
01/2001
1Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link
10/2000
1bicuculline methiodideIBA
10/2000
1Interleukin-1 Receptors (Interleukin 1 Receptor)IBA
07/2000
1Interleukin-6 (Interleukin 6)IBA
07/2000
1CytokinesIBA
07/2000
1Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
07/2000
1Interleukin-1beta (Interleukin 1 beta)IBA
07/2000
1PlasticsIBA
01/2000
1Neuropeptide Y Receptors (Neuropeptide Y Receptor)IBA
01/2000

Therapy/Procedure

2Injections
07/2000 - 01/2000